Biosensors and Bioelectronics

Biography

Biography: Jeannette Sahnghee Kim

Abstract

Existing Covid-19 virus detections are dependent on PCR amplification and electrophoresis separation instruments. Also, sterilization, virus blocking, and recognizing virus penetration is difficult in vitro human skin. For these purposes, mimic skin synthesis was performed to have high strength, waterproof function, abrasion resistance, high tensile strength, transparency, high conductivity, and functional sterilization. Simplified  antigen antibody ionic titration probe of  mimic skin tattoo fiber was prepared  using wearable circuits of cyclic, stripping, and chronoamperometry. Using potential windows of 2.0V~-2.0V amplitude and a current of 1.0×10^-3A~1.0×10^-7A, controlled programming was performed with 2D WiFi telemetric windows that can be detected in vitro or in vivo viruses instantaneously. For increased detection limits, ion amplifiers, and catalyst accelerators, chemically resistant artificial skin was modified using DNA platinum like chelate ionization multimolecular catalyst immobilizations. Here, virus assay was performed in real-time by using a tattoo coated on the skin muscle probe. A diagnosis circuit was used: a coin-sized pcb circuit with a diameter of 6 cm and a thickness of 5 mm. The system control used was the remote control program. For the application, Covid-19 virus antigen and antibody electrochemical diagnostic techniques were used. Cyclic voltammetry, stripping voltammetry, and chronoamperometry were used. The detection limits were 0.5 microlitre and 0.3 millimeters of human plasma. The measurement time was 30 to 60 seconds real-time. The measured current of the developed artificial skin sensor was measured in the range of 1.0×10^-3A ~ 1.0×10^-4A. The skin sensor was qualitatively started from 10.2ul of the plasma 0.5mL 10-fold diluted solution of the Covid-19 virus positive patient, and the working curve was confirmed with a 45 degree inclination up to 0.8uL. At this time, the measurement time was used only in 30 seconds of stripping voltammetry. For the quality of cyclic voltammetry, peaks were confirmed at -0.2V and 0.3V at oxidation potential. At the reduction potential, two reduction peaks were obtained: +0.4V and -0.3V. Therefore, it was possible to quantify that it was a Covid-19 virus with four redox peaks. The results of this study were measured on a remote skin tattoo sensor. In addition, we developed a self-diagnosis method that can be used as an assay.