Jeremiah J. Morrissey
Siteman Cancer Center, USA
Biography
Jeremiah Morrissey is in his 43rd year at Washington University School of Medicine in St. Louis. Initially in the Department of Medicine Kidney Division and since 2007 in the Department of Anesthesiology Division of Clinical and Translational Research. In 2010, he and Shrikanth Singamaneni, PhD in the Department of Mechanical Engineering Materials Science initiated a productive cross-campus collaboration resulting in many nanotechnology centered papers. Based on assay sensitivity and specificity, these talks will illustrate how improving fluorescence-based assay sensitivity and dynamic range can be used to detect low abundance biomarkers of health and disease using point of care assays. Urine, blood and interstitial fluid are basically a direct liquid biopsy of normal and pathologic organ function. Here, we have designed and synthesized an ultrabright fluorescent nanoconstruct, termed “plasmonic-fluor”, as an add-on bio-label to dramatically improve the signal-to-noise ratio of a wide variety of existing fluorescence bioassays without altering or complicating the conventional assay workflow or read-out devices.